Human cellular CYBA UTR sequences increase mRNA translation without affecting the half-life of recombinant RNA transcripts

Modified nucleotide chemistries that increase the half-life (T(1/2)) of transfected recombinant mRNA and the use of non-native 5′- and 3′-untranslated region (UTR) sequences that enhance protein translation are advancing the prospects of transcript therapy. To this end, a set of UTR sequences that a...

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Detalles Bibliográficos
Autores principales: Ferizi, Mehrije, Aneja, Manish K., Balmayor, Elizabeth R., Badieyan, Zohreh Sadat, Mykhaylyk, Olga, Rudolph, Carsten, Plank, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156912/
https://www.ncbi.nlm.nih.gov/pubmed/27974853
http://dx.doi.org/10.1038/srep39149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156912/
https://www.ncbi.nlm.nih.gov/pubmed/27974853
http://dx.doi.org/10.1038/srep39149

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