Notch regulates Th17 differentiation and controls trafficking of IL-17 and metabolic regulators within Th17 cells in a context-dependent manner

Th17 cells play critical roles in host defense and autoimmunity. Emerging data support a role for Notch signaling in Th17 cell differentiation but whether it is a positive or negative regulator remains unclear. We report here that T cell-specific deletion of Notch receptors enhances Th17 cell differ...

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Detalles Bibliográficos
Autores principales: Coutaz, Manuel, Hurrell, Benjamin P., Auderset, Floriane, Wang, Haiping, Siegert, Stefanie, Eberl, Gerard, Ho, Ping-Chih, Radtke, Freddy, Tacchini-Cottier, Fabienne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156918/
https://www.ncbi.nlm.nih.gov/pubmed/27974744
http://dx.doi.org/10.1038/srep39117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156918/
https://www.ncbi.nlm.nih.gov/pubmed/27974744
http://dx.doi.org/10.1038/srep39117

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