Biological characteristics comparison of HBV rtA181T mutants with truncated or substituted HBsAg expression in vitro and in vivo model systems

The hepatitis B virus(HBV) polymerase rtA181T mutation is selected during long-term antiviral therapy. As the polymerase gene completely overlaps with the envelope (S) gene, HBV rtA181T mutation also carries sW172 mutations. In this study, we investigated whether there were biological differences be...

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Detalles Bibliográficos
Autores principales: Zhou, Ling-Yun, Chen, En-Qiang, Wang, Meng-Lan, Chen, Lan-Lan, Liu, Cui-Ping, Zeng, Fan, Tang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157016/
https://www.ncbi.nlm.nih.gov/pubmed/27976732
http://dx.doi.org/10.1038/srep39260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157016/
https://www.ncbi.nlm.nih.gov/pubmed/27976732
http://dx.doi.org/10.1038/srep39260

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