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Genetically manipulated phages with improved pH resistance for oral administration in veterinary medicine
Orally administered phages to control zoonotic pathogens face important challenges, mainly related to the hostile conditions found in the gastrointestinal tract (GIT). These include temperature, salinity and primarily pH, which is exceptionally low in certain compartments. Phage survival under these...
Autores principales: | Nobrega, Franklin L., Costa, Ana Rita, Santos, José F., Siliakus, Melvin F., van Lent, Jan W. M., Kengen, Servé W. M., Azeredo, Joana, Kluskens, Leon D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157022/ https://www.ncbi.nlm.nih.gov/pubmed/27976713 http://dx.doi.org/10.1038/srep39235 |
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