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Plasma cell differentiation is coupled to division-dependent DNA hypomethylation and gene regulation
The epigenetic processes that regulate antibody secreting plasma cells are not well understood. Here, analysis of plasma cell differentiation revealed DNA hypomethylation of 10% of CpG loci that were overrepresented at enhancers. Inhibition of DNA methylation enhanced plasma cell commitment in a cel...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157049/ https://www.ncbi.nlm.nih.gov/pubmed/27500631 http://dx.doi.org/10.1038/ni.3519 |