Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology

BACKGROUND: Hyperphosphorylation and aggregation of tau protein are the pathological hallmarks of Alzheimer’s disease and related tauopathies. We previously demonstrated that the microglial activation induces tau hyperphosphorylation and cognitive impairment via activation of p38 mitogen-activated p...

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Detalles Bibliográficos
Autores principales: Maphis, Nicole, Jiang, Shanya, Xu, Guixiang, Kokiko-Cochran, Olga N., Roy, Saktimayee M., Van Eldik, Linda J., Watterson, D. Martin, Lamb, Bruce T., Bhaskar, Kiran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157054/
https://www.ncbi.nlm.nih.gov/pubmed/27974048
http://dx.doi.org/10.1186/s13195-016-0221-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157054/
https://www.ncbi.nlm.nih.gov/pubmed/27974048
http://dx.doi.org/10.1186/s13195-016-0221-y

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