Cargando…

Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology

BACKGROUND: Hyperphosphorylation and aggregation of tau protein are the pathological hallmarks of Alzheimer’s disease and related tauopathies. We previously demonstrated that the microglial activation induces tau hyperphosphorylation and cognitive impairment via activation of p38 mitogen-activated p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maphis, Nicole, Jiang, Shanya, Xu, Guixiang, Kokiko-Cochran, Olga N., Roy, Saktimayee M., Van Eldik, Linda J., Watterson, D. Martin, Lamb, Bruce T., Bhaskar, Kiran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157054/ https://www.ncbi.nlm.nih.gov/pubmed/27974048 http://dx.doi.org/10.1186/s13195-016-0221-y

Ejemplares similares

Loss of tau rescues inflammation-mediated neurodegeneration
por: Maphis, Nicole, et al.
Publicado: (2015)

Whole Genome Expression Analysis in a Mouse Model of Tauopathy Identifies MECP2 as a Possible Regulator of Tau Pathology
por: Maphis, Nicole M., et al.
Publicado: (2017)

Genetically enhancing the expression of chemokine domain of CX(3)CL1 fails to prevent tau pathology in mouse models of tauopathy
por: Bemiller, Shane M., et al.
Publicado: (2018)

A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction
por: Roy, Saktimayee M., et al.
Publicado: (2019)

Correction to “A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction”
por: Roy, Saktimayee M., et al.
Publicado: (2020)

Targeting Human Central Nervous System Protein Kinases: An Isoform Selective p38αMAPK Inhibitor That Attenuates Disease Progression in Alzheimer’s Disease Mouse Models
por: Roy, Saktimayee M., et al.
Publicado: (2015)

Degradation and Transmission of Tau by Autophagic-Endolysosomal Networks and Potential Therapeutic Targets for Tauopathy
por: Jiang, Shanya, et al.
Publicado: (2020)

Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes
por: Zhou, Zhengqiu, et al.
Publicado: (2017)

A novel p38α MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model
por: Munoz, Lenka, et al.
Publicado: (2007)

Ccr2 deletion dissociates cavity size and tau pathology after mild traumatic brain injury
por: Gyoneva, Stefka, et al.
Publicado: (2015)

Machine learning prediction and tau-based screening identifies potential Alzheimer’s disease genes relevant to immunity
por: Binder, Jessica, et al.
Publicado: (2022)

Triggering receptor expressed on myeloid cells 2 deficiency exacerbates injury-induced inflammation in a mouse model of tauopathy
por: Katsumoto, Atsuko, et al.
Publicado: (2022)

Interleukin-10 deficiency exacerbates inflammation-induced tau pathology
por: Weston, Lea L., et al.
Publicado: (2021)

Target Engagement Analysis and Link to Pharmacodynamic Endpoint for a Novel Class of CNS-penetrant and Efficacious p38α MAPK Inhibitors
por: Bachstetter, Adam D., et al.
Publicado: (2014)

Involvement of p38 MAPK in Synaptic Function and Dysfunction
por: Falcicchia, Chiara, et al.
Publicado: (2020)

TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy
por: Bemiller, Shane M., et al.
Publicado: (2017)

p38δ MAPK: Emerging Roles of a Neglected Isoform
por: O'Callaghan, Carol, et al.
Publicado: (2014)

Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway
por: Jiang, Shanya, et al.
Publicado: (2021)

Therapeutic treatment with the anti-inflammatory drug candidate MW151 may partially reduce memory impairment and normalizes hippocampal metabolic markers in a mouse model of comorbid amyloid and vascular pathology
por: Braun, David J., et al.
Publicado: (2022)

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)
por: Bachstetter, Adam D, et al.
Publicado: (2011)

SMaRT modulation of tau isoforms rescues cognitive and motor impairments in a preclinical model of tauopathy
por: Muñiz, Javier Andrés, et al.
Publicado: (2022)

Inhibition of Neuronal p38α, but not p38β MAPK, Provides Neuroprotection Against Three Different Neurotoxic Insults
por: Xing, Bin, et al.
Publicado: (2014)

Selective In Vitro and Ex Vivo Staining of Brain Neurofibrillary Tangles and Amyloid Plaques by Novel Ethylene Ethynylene-Based Optical Sensors
por: Monge, Florencia A., et al.
Publicado: (2023)

Tau in MAPK Activation
por: Leugers, Chad J., et al.
Publicado: (2013)

CD40 Signaling Is Impaired in L. major–infected Macrophages and Is Rescued by a p38MAPK Activator Establishing a Host-protective Memory T Cell Response
por: Awasthi, Amit, et al.
Publicado: (2003)

Inhibiting p38 MAPK alpha rescues axonal retrograde transport defects in a mouse model of ALS
por: Gibbs, Katherine L., et al.
Publicado: (2018)

p38 MAPK in MDS
por: Gañán‐Gómez, Irene, et al.
Publicado: (2015)

Deletion of p38α MAPK in microglia blunts trauma-induced inflammatory responses in mice
por: Morganti, Josh M., et al.
Publicado: (2019)

The p38α mitogen-activated protein kinase as a central nervous system drug discovery target
por: Borders, Aaron S, et al.
Publicado: (2008)

A Levee to the Flood: Pre-injury Neuroinflammation and Immune Stress Influence Traumatic Brain Injury Outcome
por: Houle, Samuel, et al.
Publicado: (2022)

Diagnostic Significance of p38 Isoforms (p38α, p38β, p38γ, p38δ) in Head and Neck Squamous Cell Carcinoma: Comparative Serum Level Evaluation and Design of Novel Peptide Inhibitor Targeting the Same
por: Sahu, Vishal, et al.
Publicado: (2019)

Direct Transcriptional Control of a p38 MAPK Pathway by the Circadian Clock in Neurospora crassa
por: Lamb, Teresa M., et al.
Publicado: (2011)

Human Tau Isoforms and Proteolysis for Production of Toxic Tau Fragments in Neurodegeneration
por: Boyarko, Ben, et al.
Publicado: (2021)

Investigation of the role of the p38 MAPK α and δ isoforms in nonresponse to tumour necrosis factor blockade in the synovium of rheumatoid arthritis patients
por: Coulthard, LR, et al.
Publicado: (2007)

The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer’s Disease
por: Kokiko-Cochran, Olga N., et al.
Publicado: (2018)

p38γ and p38δ Mitogen Activated Protein Kinases (MAPKs), New Stars in the MAPK Galaxy
por: Escós, Alejandra, et al.
Publicado: (2016)

p38α MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse
por: Robson, Matthew J., et al.
Publicado: (2018)

Three Repeat Isoforms of Tau Inhibit Assembly of Four Repeat Tau Filaments
por: Adams, Stephanie J., et al.
Publicado: (2010)

Tau Isoform-Driven CBD Pathology Transmission in Oligodendrocytes in Humanized Tau Mice
por: Zareba-Paslawska, Justyna, et al.
Publicado: (2021)

Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα
por: Xing, Bin, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_79kbp9h4qvbd6ulovel0u84f6d