Effects of protonation on the hydrolysis of triphosphate in vacuum and the implications for catalysis by nucleotide hydrolyzing enzymes

BACKGROUND: Nucleoside triphosphate (NTP) hydrolysis is a key reaction in biology. It involves breaking two very stable bonds (one P–O bond and one O–H bond of water), in either a concurrent or a sequential way. Here, we systematically examine how protonation of the triphosphate affects the mechanis...

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Detalles Bibliográficos
Autores principales: Kiani, Farooq Ahmad, Fischer, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157097/
https://www.ncbi.nlm.nih.gov/pubmed/27974044
http://dx.doi.org/10.1186/s12858-016-0068-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157097/
https://www.ncbi.nlm.nih.gov/pubmed/27974044
http://dx.doi.org/10.1186/s12858-016-0068-7

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