Central Ceramide-Induced Hypothalamic Lipotoxicity and ER Stress Regulate Energy Balance

Hypothalamic endoplasmic reticulum (ER) stress is a key mechanism leading to obesity. Here, we demonstrate that ceramides induce lipotoxicity and hypothalamic ER stress, leading to sympathetic inhibition, reduced brown adipose tissue (BAT) thermogenesis, and weight gain. Genetic overexpression of th...

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Detalles Bibliográficos
Autores principales: Contreras, Cristina, González-García, Ismael, Martínez-Sánchez, Noelia, Seoane-Collazo, Patricia, Jacas, Jordi, Morgan, Donald A., Serra, Dolors, Gallego, Rosalía, Gonzalez, Francisco, Casals, Núria, Nogueiras, Rubén, Rahmouni, Kamal, Diéguez, Carlos, López, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157160/
https://www.ncbi.nlm.nih.gov/pubmed/25284795
http://dx.doi.org/10.1016/j.celrep.2014.08.057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157160/
https://www.ncbi.nlm.nih.gov/pubmed/25284795
http://dx.doi.org/10.1016/j.celrep.2014.08.057

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