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Tumor Suppressor Genes within Common Fragile Sites Are Active Players in the DNA Damage Response
The role of common fragile sites (CFSs) in cancer remains controversial. Two main views dominate the discussion: one suggests that CFS loci are hotspots of genomic instability leading to inactivation of genes encoded within them, while the other view proposes that CFSs are functional units and that...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157955/ https://www.ncbi.nlm.nih.gov/pubmed/27977694 http://dx.doi.org/10.1371/journal.pgen.1006436 |