Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence

The opportunistic fungal pathogen Cryptococcus neoformans is a major cause of mortality in immunocompromised individuals, resulting in more than 600,000 deaths per year. Many human fungal pathogens secrete peptidases that influence virulence, but in most cases the substrate specificity and regulatio...

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Detalles Bibliográficos
Autores principales: Clarke, Starlynn C., Dumesic, Phillip A., Homer, Christina M., O’Donoghue, Anthony J., La Greca, Florencia, Pallova, Lenka, Majer, Pavel, Madhani, Hiten D., Craik, Charles S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5158083/
https://www.ncbi.nlm.nih.gov/pubmed/27977806
http://dx.doi.org/10.1371/journal.ppat.1006051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5158083/
https://www.ncbi.nlm.nih.gov/pubmed/27977806
http://dx.doi.org/10.1371/journal.ppat.1006051

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