Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized to Improve Immune Protection by CMV-Based Vaccine Vectors

Cytomegalovirus (CMV) elicits long-term T-cell immunity of unparalleled strength, which has allowed the development of highly protective CMV-based vaccine vectors. Counterintuitively, experimental vaccines encoding a single MHC-I restricted epitope offered better immune protection than those express...

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Detalles Bibliográficos
Autores principales: Dekhtiarenko, Iryna, Ratts, Robert B., Blatnik, Renata, Lee, Lian N., Fischer, Sonja, Borkner, Lisa, Oduro, Jennifer D., Marandu, Thomas F., Hoppe, Stephanie, Ruzsics, Zsolt, Sonnemann, Julia K., Mansouri, Mandana, Meyer, Christine, Lemmermann, Niels A. W., Holtappels, Rafaela, Arens, Ramon, Klenerman, Paul, Früh, Klaus, Reddehase, Matthias J., Riemer, Angelika B., Cicin-Sain, Luka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5158087/
https://www.ncbi.nlm.nih.gov/pubmed/27977791
http://dx.doi.org/10.1371/journal.ppat.1006072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5158087/
https://www.ncbi.nlm.nih.gov/pubmed/27977791
http://dx.doi.org/10.1371/journal.ppat.1006072

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