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Pertussis Toxin Is a Robust and Selective Inhibitor of High Grade Glioma Cell Migration and Invasion
In high grade glioma (HGG), extensive tumor cell infiltration of normal brain typically precludes identifying effective margins for surgical resection or irradiation. Pertussis toxin (PT) is a multimeric complex that inactivates diverse G(i/o) G-protein coupled receptors (GPCRs). Despite the broad c...
Autores principales: | Gilder, Andrew S., Wang, Lei, Natali, Letizia, Karimi-Mostowfi, Nicki, Brifault, Coralie, Gonias, Steven L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5158192/ https://www.ncbi.nlm.nih.gov/pubmed/27977780 http://dx.doi.org/10.1371/journal.pone.0168418 |
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