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Enhanced Expression of Trib3 during the Development of Myelin Breakdown in dmy Myelin Mutant Rats

The demyelination (dmy) rat exhibits hind limb ataxia and severe myelin breakdown in the central nervous system. The causative gene of dmy rats is the MRS2 magnesium transporter gene. Tribbles homolog 3 (Trib3) is a pseudokinase molecule that modifies certain signal pathways, and its expression is i...

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Detalles Bibliográficos
Autores principales: Shimotsuma, Yukako, Tanaka, Miyuu, Izawa, Takeshi, Yamate, Jyoji, Kuwamura, Mitsuru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5158197/
https://www.ncbi.nlm.nih.gov/pubmed/27977799
http://dx.doi.org/10.1371/journal.pone.0168250