Prediction of Deoxypodophyllotoxin Disposition in Mouse, Rat, Monkey, and Dog by Physiologically Based Pharmacokinetic Model and the Extrapolation to Human

Deoxypodophyllotoxin (DPT) is a potential anti-tumor candidate prior to its clinical phase. The aim of the study was to develop a physiologically based pharmacokinetic (PBPK) model consisting of 13 tissue compartments to predict DPT disposition in mouse, rat, monkey, and dog based on in vitro and in...

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Detalles Bibliográficos
Autores principales: Chen, Yang, Zhao, Kaijing, Liu, Fei, Xie, Qiushi, Zhong, Zeyu, Miao, Mingxing, Liu, Xiaodong, Liu, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159431/
https://www.ncbi.nlm.nih.gov/pubmed/28018224
http://dx.doi.org/10.3389/fphar.2016.00488

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159431/
https://www.ncbi.nlm.nih.gov/pubmed/28018224
http://dx.doi.org/10.3389/fphar.2016.00488

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