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Progressive Seizure Aggravation in the Repeated 6-Hz Corneal Stimulation Model Is Accompanied by Marked Increase in Hippocampal p-ERK1/2 Immunoreactivity in Neurons
The 6-Hz corneal stimulation test is used to screen novel antiepileptic molecules to overcome the problem of drug refractoriness. Although recognized as a standard test, it has been evaluated only recently in the attempt to characterize the putative neuronal networks involved in seizures caused by c...
Autores principales: | Giordano, Carmela, Costa, Anna M., Lucchi, Chiara, Leo, Giuseppina, Brunel, Luc, Fehrentz, Jean-Alain, Martinez, Jean, Torsello, Antonio, Biagini, Giuseppe |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159434/ https://www.ncbi.nlm.nih.gov/pubmed/28018175 http://dx.doi.org/10.3389/fncel.2016.00281 |
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