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Nucleic acid clamp-mediated recognition and stabilization of the physiologically relevant MYC promoter G-quadruplex
The MYC proto-oncogene is upregulated, often at the transcriptional level, in ∼80% of all cancers. MYC's promoter is governed by a higher order G-quadruplex (G4) structure in the NHE III(1) region. Under a variety of conditions, multiple isoforms have been described to form from the first four...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159522/ https://www.ncbi.nlm.nih.gov/pubmed/27789698 http://dx.doi.org/10.1093/nar/gkw1006 |