Nucleolytic processing of aberrant replication intermediates by an Exo1-Dna2-Sae2 axis counteracts fork collapse-driven chromosome instability

Problems during DNA replication underlie genomic instability and drive malignant transformation. The DNA damage checkpoint stabilizes stalled replication forks thus counteracting aberrant fork transitions, DNA breaks and chromosomal rearrangements. We analyzed fork processing in checkpoint deficient...

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Detalles Bibliográficos
Autores principales: Colosio, Arianna, Frattini, Camilla, Pellicanò, Grazia, Villa-Hernández, Sara, Bermejo, Rodrigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159547/
https://www.ncbi.nlm.nih.gov/pubmed/27672038
http://dx.doi.org/10.1093/nar/gkw858

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159547/
https://www.ncbi.nlm.nih.gov/pubmed/27672038
http://dx.doi.org/10.1093/nar/gkw858

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