Adaptive upregulation of DNA repair genes following benzo(a)pyrene diol epoxide protects against cell death at the expense of mutations

A coordinated and faithful DNA damage response is of central importance for maintaining genomic integrity and survival. Here, we show that exposure of human cells to benzo(a)pyrene 9,10-diol-7,8-epoxide (BPDE), the active metabolite of benzo(a)pyrene (B(a)P), which represents a most important carcin...

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Detalles Bibliográficos
Autores principales: Christmann, Markus, Boisseau, Catherine, Kitzinger, Rebekka, Berac, Christian, Allmann, Sebastian, Sommer, Tina, Aasland, Dorthe, Kaina, Bernd, Tomicic, Maja T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159553/
https://www.ncbi.nlm.nih.gov/pubmed/27694624
http://dx.doi.org/10.1093/nar/gkw873

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159553/
https://www.ncbi.nlm.nih.gov/pubmed/27694624
http://dx.doi.org/10.1093/nar/gkw873

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