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Cholinergic Interneurons Amplify Corticostriatal Synaptic Responses in the Q175 Model of Huntington’s Disease

Huntington’s disease (HD) is a neurodegenerative disorder characterized by deficits in movement control that are widely viewed as stemming from pathophysiological changes in the striatum. Giant, aspiny cholinergic interneurons (ChIs) are key elements in the striatal circuitry controlling movement, b...

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Detalles Bibliográficos
Autores principales: Tanimura, Asami, Lim, Sean Austin O., Aceves Buendia, Jose de Jesus, Goldberg, Joshua A., Surmeier, D. James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159611/
https://www.ncbi.nlm.nih.gov/pubmed/28018188
http://dx.doi.org/10.3389/fnsys.2016.00102