Global analysis of pre-mRNA subcellular localization following splicing inhibition by spliceostatin A

Spliceostatin A (SSA) is a methyl ketal derivative of FR901464, a potent antitumor compound isolated from a culture broth of Pseudomonas sp. no. 2663. These compounds selectively bind to the essential spliceosome component SF3b, a subcomplex of the U2 snRNP, to inhibit pre-mRNA splicing. However, th...

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Detalles Bibliográficos
Autores principales: Yoshimoto, Rei, Kaida, Daisuke, Furuno, Masaaki, Burroughs, A. Maxwell, Noma, Shohei, Suzuki, Harukazu, Kawamura, Yumi, Hayashizaki, Yoshihide, Mayeda, Akila, Yoshida, Minoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159648/
https://www.ncbi.nlm.nih.gov/pubmed/27754875
http://dx.doi.org/10.1261/rna.058065.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159648/
https://www.ncbi.nlm.nih.gov/pubmed/27754875
http://dx.doi.org/10.1261/rna.058065.116

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