Harnessing the natural inhibitory domain to control TNFα Converting Enzyme (TACE) activity in vivo

Dysregulated activity of A Disintegrin And Metalloproteinase 17 (ADAM17)/TNFα Converting Enzyme (TACE) is associated with inflammatory disorders and cancer progression by releasing regulatory membrane-tethered proteins like TNFα, IL6R and EGFR ligands. Although specific inhibition of TACE is thought...

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Detalles Bibliográficos
Autores principales: Wong, Eitan, Cohen, Tal, Romi, Erez, Levin, Maxim, Peleg, Yoav, Arad, Uri, Yaron, Avraham, Milla, Marcos E., Sagi, Irit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159831/
https://www.ncbi.nlm.nih.gov/pubmed/27982031
http://dx.doi.org/10.1038/srep35598

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159831/
https://www.ncbi.nlm.nih.gov/pubmed/27982031
http://dx.doi.org/10.1038/srep35598

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