The involvement of dityrosine crosslinking in α-synuclein assembly and deposition in Lewy Bodies in Parkinson’s disease

Parkinson’s disease (PD) is characterized by intracellular, insoluble Lewy bodies composed of highly stable α-synuclein (α-syn) amyloid fibrils. α-synuclein is an intrinsically disordered protein that has the capacity to assemble to form β-sheet rich fibrils. Oxidiative stress and metal rich environ...

Descripción completa

Detalles Bibliográficos
Autores principales: Al-Hilaly, Youssra K., Biasetti, Luca, Blakeman, Ben J. F., Pollack, Saskia J., Zibaee, Shahin, Abdul-Sada, Alaa, Thorpe, Julian R., Xue, Wei-Feng, Serpell, Louise C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159849/
https://www.ncbi.nlm.nih.gov/pubmed/27982082
http://dx.doi.org/10.1038/srep39171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159849/
https://www.ncbi.nlm.nih.gov/pubmed/27982082
http://dx.doi.org/10.1038/srep39171

Ejemplares similares