Cargando…

The involvement of dityrosine crosslinking in α-synuclein assembly and deposition in Lewy Bodies in Parkinson’s disease

Parkinson’s disease (PD) is characterized by intracellular, insoluble Lewy bodies composed of highly stable α-synuclein (α-syn) amyloid fibrils. α-synuclein is an intrinsically disordered protein that has the capacity to assemble to form β-sheet rich fibrils. Oxidiative stress and metal rich environ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Al-Hilaly, Youssra K., Biasetti, Luca, Blakeman, Ben J. F., Pollack, Saskia J., Zibaee, Shahin, Abdul-Sada, Alaa, Thorpe, Julian R., Xue, Wei-Feng, Serpell, Louise C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159849/ https://www.ncbi.nlm.nih.gov/pubmed/27982082 http://dx.doi.org/10.1038/srep39171

Ejemplares similares

A central role for dityrosine crosslinking of Amyloid-β in Alzheimer’s disease
por: Al-Hilaly, Youssra K, et al.
Publicado: (2013)

Dityrosine cross-linking and its potential roles in Alzheimer’s disease
por: Maina, Mahmoud B., et al.
Publicado: (2023)

Changing mechanical properties of photopolymerized, dityrosine-crosslinked protein-based hydrogels
por: Haas, Sandra, et al.
Publicado: (2022)

Structural Basis for Dityrosine-Mediated Inhibition of α-Synuclein Fibrillization
por: Sahin, Cagla, et al.
Publicado: (2022)

Paired Helical Filament-Forming Region of Tau (297–391) Influences Endogenous Tau Protein and Accumulates in Acidic Compartments in Human Neuronal Cells
por: Pollack, Saskia J., et al.
Publicado: (2020)

Opposed Effects of Dityrosine Formation in Soluble and Aggregated α-Synuclein on Fibril Growth
por: Wördehoff, Michael M., et al.
Publicado: (2017)

Mapping of Photochemically-Derived Dityrosine across Fe-Bound N-Acetylated α-Synuclein
por: Curry, Alyson M., et al.
Publicado: (2020)

Tau (297‐391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer’s disease brain
por: Al‐Hilaly, Youssra K., et al.
Publicado: (2019)

Megadalton-sized Dityrosine Aggregates of α-Synuclein Retain High Degrees of Structural Disorder and Internal Dynamics
por: Verzini, Silvia, et al.
Publicado: (2020)

Nuclear Tau and Its Potential Role in Alzheimer’s Disease
por: Bukar Maina, Mahmoud, et al.
Publicado: (2016)

Large-Scale Qualitative and Quantitative Assessment of Dityrosine Crosslinking Omics in Response to Endogenous and Exogenous Hydrogen Peroxide in Escherichia coli
por: Zhou, Xiangzhe, et al.
Publicado: (2023)

Dityrosine Crosslinking of Collagen and Amyloid-β Peptides Is Formed by Vitamin B(12) Deficiency-Generated Oxidative Stress in Caenorhabditis elegans
por: Koseki, Kyohei, et al.
Publicado: (2021)

Longitudinal live imaging of retinal α-synuclein::GFP deposits in a transgenic mouse model of Parkinson’s Disease/Dementia with Lewy Bodies
por: Price, Diana L., et al.
Publicado: (2016)

Crystal Crosslinked Gels for the Deposition of Inorganic Salts with Polyhedral Shapes
por: Mochizuki, Yumi, et al.
Publicado: (2018)

Shapeshifting tau: from intrinsically disordered to paired-helical filaments
por: Mengham, Kurtis, et al.
Publicado: (2022)

The synaptic pathology of α-synuclein aggregation in dementia with Lewy bodies, Parkinson’s disease and Parkinson’s disease dementia
por: Schulz-Schaeffer, Walter J.
Publicado: (2010)

The involvement of tau in nucleolar transcription and the stress response
por: Maina, Mahmoud B., et al.
Publicado: (2018)

Metal- and UV- Catalyzed Oxidation Results in Trapped Amyloid-β Intermediates Revealing that Self-Assembly Is Required for Aβ-Induced Cytotoxicity
por: Maina, Mahmoud B., et al.
Publicado: (2020)

Structural Identification of Individual Helical Amyloid Filaments by Integration of Cryo-Electron Microscopy-Derived Maps in Comparative Morphometric Atomic Force Microscopy Image Analysis
por: Lutter, Liisa, et al.
Publicado: (2022)

Alpha-Synuclein Oligomers—Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders
por: Ingelsson, Martin
Publicado: (2016)

The Role of Cholesterol in α‐Synuclein and Lewy Body Pathology in GBA1 Parkinson's Disease
por: García‐Sanz, Patricia, et al.
Publicado: (2020)

Discrepancy between distribution of alpha-synuclein oligomers and Lewy-related pathology in Parkinson’s disease
por: Sekiya, Hiroaki, et al.
Publicado: (2022)

Non-cytotoxic Dityrosine Photocrosslinked Polymeric Materials With Targeted Elastic Moduli
por: Camp, Christopher P., et al.
Publicado: (2020)

α-Synuclein Strains and Their Relevance to Parkinson’s Disease, Multiple System Atrophy, and Dementia with Lewy Bodies
por: Graves, Noah J., et al.
Publicado: (2023)

Alpha-synuclein biology in Lewy body diseases
por: Kim, Woojin Scott, et al.
Publicado: (2014)

Detection of Dermal Alpha-Synuclein Deposits as a Biomarker for Parkinson’s Disease
por: Doppler, Kathrin
Publicado: (2021)

Differential insular cortex subregional vulnerability to α‐synuclein pathology in Parkinson's disease and dementia with Lewy bodies
por: Fathy, Y. Y., et al.
Publicado: (2018)

Anti-amyloid Compounds Inhibit α-Synuclein Aggregation Induced by Protein Misfolding Cyclic Amplification (PMCA)
por: Herva, Maria Eugenia, et al.
Publicado: (2014)

Skin alpha-synuclein deposit patterns: A predictor of Parkinson's disease subtypes
por: Han, Yihang, et al.
Publicado: (2022)

The Role of Alpha-Synuclein Deposits in Parkinson’s Disease: A Focus on the Human Retina
por: Di Pippo, Mariachiara, et al.
Publicado: (2023)

Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson’s disease and dementia with Lewy bodies
por: Stuendl, Anne, et al.
Publicado: (2016)

Progressive aggregation of alpha-synuclein and selective degeneration of Lewy inclusion-bearing neurons in a mouse model of parkinsonism
por: Osterberg, Valerie R., et al.
Publicado: (2015)

Streamlined alpha-synuclein RT-QuIC assay for various biospecimens in Parkinson’s disease and dementia with Lewy bodies
por: Bargar, Connor, et al.
Publicado: (2021)

Association between CSF alpha-synuclein seeding activity and genetic status in Parkinson’s disease and dementia with Lewy bodies
por: Brockmann, Kathrin, et al.
Publicado: (2021)

Lewy Body-Associated Proteins A-Synuclein (a-syn) as a Plasma-Based Biomarker for Parkinson’s Disease
por: Zhao, Xuemiao, et al.
Publicado: (2022)

The Structure of Cross‐β Tapes and Tubes Formed by an Octapeptide, αSβ1
por: Morris, Kyle L., et al.
Publicado: (2013)

The Molecular Basis for Apolipoprotein E4 as the Major Risk Factor for Late-Onset Alzheimer's Disease
por: Raulin, Ana-Caroline, et al.
Publicado: (2019)

Tau Filament Self-Assembly and Structure: Tau as a Therapeutic Target
por: Oakley, Sebastian S., et al.
Publicado: (2020)

Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297–391) Intermediates
por: Maina, Mahmoud B., et al.
Publicado: (2021)

Dermal Phospho-Alpha-Synuclein Deposition in Patients With Parkinson's Disease and Mutation of the Glucocerebrosidase Gene
por: Doppler, Kathrin, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ebe3lfr9g9al7532nhudigs4nd