Efficient DNA–Polymer Coupling in Organic Solvents: A Survey of Amide Coupling, Thiol-Ene and Tetrazine–Norbornene Chemistries Applied to Conjugation of Poly(N-Isopropylacrylamide)

A range of chemistries were explored for the efficient covalent conjugation of DNA to poly(N-isopropylacrylamide) (poly(NIPAM)) in organic solvents. Amide coupling and thiol–ene Michael addition were found to be ineffective for the synthesis of the desired products. However, the inverse electron-dem...

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Detalles Bibliográficos
Autores principales: Wilks, Thomas R., O’Reilly, Rachel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159856/
https://www.ncbi.nlm.nih.gov/pubmed/27982070
http://dx.doi.org/10.1038/srep39192

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159856/
https://www.ncbi.nlm.nih.gov/pubmed/27982070
http://dx.doi.org/10.1038/srep39192

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