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Protein knotting through concatenation significantly reduces folding stability

Concatenation by covalent linkage of two protomers of an intertwined all-helical HP0242 homodimer from Helicobacter pylori results in the first example of an engineered knotted protein. While concatenation does not affect the native structure according to X-ray crystallography, the folding kinetics...

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Detalles Bibliográficos
Autor principal: Hsu, Shang-Te Danny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159899/
https://www.ncbi.nlm.nih.gov/pubmed/27982106
http://dx.doi.org/10.1038/srep39357