A structural insight into the negative effects of opioids in analgesia by modulating the TLR4 signaling: An in silico approach

Opioids are considered the gold standard therapy for pain. However, TLR-dependent negative effects in analgesia have highlighted the complexities in the pharmacodynamics of opioids. While successive studies have reported that morphine and Morphine-3-glucuronide (M3G) activate the TLR4 pathway, the s...

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Detalles Bibliográficos
Autores principales: Shah, Masaud, Anwar, Muhammad Ayaz, Yesudhas, Dhanusha, Krishnan, Jayalakshmi, Choi, Sangdun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159903/
https://www.ncbi.nlm.nih.gov/pubmed/27982096
http://dx.doi.org/10.1038/srep39271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159903/
https://www.ncbi.nlm.nih.gov/pubmed/27982096
http://dx.doi.org/10.1038/srep39271

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