Spontaneous Isopeptide Bond Formation as a Powerful Tool for Engineering Site-Specific Antibody-Drug Conjugates

Spontaneous isopeptide bond formation, a stabilizing posttranslational modification that can be found in gram-positive bacterial cell surface proteins, has previously been used to develop a peptide-peptide ligation technology that enables the polymerization of tagged-proteins catalyzed by SpyLigase....

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Detalles Bibliográficos
Autores principales: Siegmund, Vanessa, Piater, Birgit, Zakeri, Bijan, Eichhorn, Thomas, Fischer, Frank, Deutsch, Carl, Becker, Stefan, Toleikis, Lars, Hock, Björn, Betz, Ulrich A. K., Kolmar, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159917/
https://www.ncbi.nlm.nih.gov/pubmed/27982100
http://dx.doi.org/10.1038/srep39291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159917/
https://www.ncbi.nlm.nih.gov/pubmed/27982100
http://dx.doi.org/10.1038/srep39291

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