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Estimates of statistical significance for comparison of individual positions in multiple sequence alignments
BACKGROUND: Profile-based analysis of multiple sequence alignments (MSA) allows for accurate comparison of protein families. Here, we address the problems of detecting statistically confident dissimilarities between (1) MSA position and a set of predicted residue frequencies, and (2) between two MSA...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2004
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC516024/ https://www.ncbi.nlm.nih.gov/pubmed/15296518 http://dx.doi.org/10.1186/1471-2105-5-106 |