Simultaneous paralogue knockout using a CRISPR-concatemer in mouse small intestinal organoids

Approaches based on genetic modification have been invaluable for investigating a wide array of biological processes, with gain- and loss-of-function approaches frequently used to investigate gene function. However, the presence of paralogues, and hence possible genetic compensation, for many genes...

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Detalles Bibliográficos
Autores principales: Andersson-Rolf, Amanda, Merenda, Alessandra, Mustata, Roxana C., Li, Taibo, Dietmann, Sabine, Koo, Bon-Kyoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161140/
https://www.ncbi.nlm.nih.gov/pubmed/27983963
http://dx.doi.org/10.1016/j.ydbio.2016.10.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161140/
https://www.ncbi.nlm.nih.gov/pubmed/27983963
http://dx.doi.org/10.1016/j.ydbio.2016.10.016

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