Estimation of Maximum Recommended Therapeutic Dose Using Predicted Promiscuity and Potency

We report a simple model that predicts the maximum recommended therapeutic dose (MRTD) of small molecule drugs based on an assessment of likely protein–drug interactions. Previously, we reported methods for computational estimation of drug promiscuity and potency. We used these concepts to build a l...

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Detalles Bibliográficos
Autores principales: Liu, T, Oprea, T, Ursu, O, Hasselgren, C, Altman, RB
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161261/
https://www.ncbi.nlm.nih.gov/pubmed/27736015
http://dx.doi.org/10.1111/cts.12422