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Estimation of Maximum Recommended Therapeutic Dose Using Predicted Promiscuity and Potency
We report a simple model that predicts the maximum recommended therapeutic dose (MRTD) of small molecule drugs based on an assessment of likely protein–drug interactions. Previously, we reported methods for computational estimation of drug promiscuity and potency. We used these concepts to build a l...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161261/ https://www.ncbi.nlm.nih.gov/pubmed/27736015 http://dx.doi.org/10.1111/cts.12422 |