Stochasticity in the Genotype-Phenotype Map: Implications for the Robustness and Persistence of Bet-Hedging

Nongenetic variation in phenotypes, or bet-hedging, has been observed as a driver of drug resistance in both bacterial infections and cancers. Here, we study how bet-hedging emerges in genotype–phenotype (GP) mapping through a simple interaction model: a molecular switch. We use simple chemical reac...

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Detalles Bibliográficos
Autores principales: Nichol, Daniel, Robertson-Tessi, Mark, Jeavons, Peter, Anderson, Alexander R.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2016
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161283/
https://www.ncbi.nlm.nih.gov/pubmed/27770034
http://dx.doi.org/10.1534/genetics.116.193474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161283/
https://www.ncbi.nlm.nih.gov/pubmed/27770034
http://dx.doi.org/10.1534/genetics.116.193474

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