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Stochasticity in the Genotype-Phenotype Map: Implications for the Robustness and Persistence of Bet-Hedging
Nongenetic variation in phenotypes, or bet-hedging, has been observed as a driver of drug resistance in both bacterial infections and cancers. Here, we study how bet-hedging emerges in genotype–phenotype (GP) mapping through a simple interaction model: a molecular switch. We use simple chemical reac...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Genetics Society of America
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161283/ https://www.ncbi.nlm.nih.gov/pubmed/27770034 http://dx.doi.org/10.1534/genetics.116.193474 |