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Role of polysaccharide and lipid in lipopolysaccharide induced prion protein conversion
Conversion of native cellular prion protein (PrP(c)) from an α-helical structure to a toxic and infectious β-sheet structure (PrP(Sc)) is a critical step in the development of prion disease. There are some indications that the formation of PrP(Sc) is preceded by a β-sheet rich PrP (PrP(β)) form whic...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161299/ https://www.ncbi.nlm.nih.gov/pubmed/27906600 http://dx.doi.org/10.1080/19336896.2016.1254857 |