Phospholamban Ablation Using CRISPR/Cas9 System Improves Mortality in a Murine Heart Failure Model

Sarcoplasmic reticulum Ca(2+)-ATPase 2a (SERCA2a) and its inhibitory protein called phospholamban (PLN) are pivotal for Ca(2+) handling in cardiomyocyte and are known that their expression level and activity were changed in the heart failure patients. To examine whether PLN inhibition can improve su...

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Detalles Bibliográficos
Autores principales: Kaneko, Manami, Hashikami, Kentarou, Yamamoto, Satoshi, Matsumoto, Hirokazu, Nishimoto, Tomoyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161475/
https://www.ncbi.nlm.nih.gov/pubmed/27992596
http://dx.doi.org/10.1371/journal.pone.0168486

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161475/
https://www.ncbi.nlm.nih.gov/pubmed/27992596
http://dx.doi.org/10.1371/journal.pone.0168486

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