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Phospholamban Ablation Using CRISPR/Cas9 System Improves Mortality in a Murine Heart Failure Model
Sarcoplasmic reticulum Ca(2+)-ATPase 2a (SERCA2a) and its inhibitory protein called phospholamban (PLN) are pivotal for Ca(2+) handling in cardiomyocyte and are known that their expression level and activity were changed in the heart failure patients. To examine whether PLN inhibition can improve su...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161475/ https://www.ncbi.nlm.nih.gov/pubmed/27992596 http://dx.doi.org/10.1371/journal.pone.0168486 |