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Oxidative diversification of amino acids and peptides by small-molecule iron catalysis

Secondary metabolites synthesized by nonribosomal peptide synthetases (NRPSs) display diverse and complex topologies and possess an impressive range of biological activities(1,2) Much of this diversity derives from a synthetic strategy that entails the oxidation of both the chiral amino acid buildin...

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Detalles Bibliográficos
Autores principales: Osberger, Thomas J., Rogness, Donald C., Kohrt, Jeffrey T., Stepan, Antonia F., White, M. Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161617/
https://www.ncbi.nlm.nih.gov/pubmed/27479323
http://dx.doi.org/10.1038/nature18941