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Ubiquitin Utilizes an Acidic Surface Patch to Alter Chromatin Structure
Ubiquitylation of histone H2B, associated with gene activation, leads to chromatin decompaction through an unknown mechanism. We used a hydrogen-deuterium exchange strategy coupled with nuclear magnetic resonance spectroscopy to map the ubiquitin surface responsible for its structural effects on chr...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161692/ https://www.ncbi.nlm.nih.gov/pubmed/27870837 http://dx.doi.org/10.1038/nchembio.2235 |