Integrated genomic analysis of colorectal cancer progression reveals activation of EGFR through demethylation of the EREG promoter

Key molecular drivers that underlie transformation of colonic epithelium into colorectal adenocarcinoma (CRC) are well described. However, the mechanisms through which clinically targeted pathways are activated during CRC progression have yet to be elucidated. Here, we used an integrative genomics a...

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Detalles Bibliográficos
Autores principales: Qu, X, Sandmann, T, Frierson, H, Fu, L, Fuentes, E, Walter, K, Okrah, K, Rumpel, C, Moskaluk, C, Lu, S, Wang, Y, Bourgon, R, Penuel, E, Pirzkall, A, Amler, L, Lackner, M R, Tabernero, J, Hampton, G M, Kabbarah, O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161754/
https://www.ncbi.nlm.nih.gov/pubmed/27270421
http://dx.doi.org/10.1038/onc.2016.170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161754/
https://www.ncbi.nlm.nih.gov/pubmed/27270421
http://dx.doi.org/10.1038/onc.2016.170

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