A novel independence test for somatic alterations in cancer shows that biology drives mutual exclusivity but chance explains most co-occurrence

In cancer, mutually exclusive or co-occurring somatic alterations across genes can suggest functional interactions. Existing tests for such patterns make the unrealistic assumption of identical gene alteration probabilities across tumors. We present Discrete Independence Statistic Controlling for Ob...

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Detalles Bibliográficos
Autores principales: Canisius, Sander, Martens, John W. M., Wessels, Lodewyk F. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5162102/
https://www.ncbi.nlm.nih.gov/pubmed/27986087
http://dx.doi.org/10.1186/s13059-016-1114-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5162102/
https://www.ncbi.nlm.nih.gov/pubmed/27986087
http://dx.doi.org/10.1186/s13059-016-1114-x

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