Preventative and therapeutic effects of a GABA transporter 1 inhibitor administered systemically in a mouse model of paclitaxel-induced neuropathic pain

BACKGROUND: There is a dearth of drugs to manage a dose-limiting painful peripheral neuropathy induced by paclitaxel in some patients during the treatment of cancer. Gamma-aminobutyric acid transporter-1 (GAT-1) whose expression is increased in the brain and spinal cord during paclitaxel-induced neu...

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Detalles Bibliográficos
Autores principales: Masocha, Willias, Parvathy, Subramanian S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2016
Materias:
Animal Behavior
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5162398/
https://www.ncbi.nlm.nih.gov/pubmed/27994987
http://dx.doi.org/10.7717/peerj.2798

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5162398/
https://www.ncbi.nlm.nih.gov/pubmed/27994987
http://dx.doi.org/10.7717/peerj.2798

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