Discovery of novel inhibitors disrupting HIF-1α/von Hippel–Lindau interaction through shape-based screening and cascade docking

Major research efforts have been devoted to the discovery and development of new chemical entities that could inhibit the protein–protein interaction between HIF-1α and the von Hippel–Lindau protein (pVHL), which serves as the substrate recognition subunit of an E3 ligase and is regarded as a crucia...

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Detalles Bibliográficos
Autores principales: Xue, Xin, Zhao, Ning-Yi, Yu, Hai-Tao, Sun, Yuan, Kang, Chen, Huang, Qiong-Bin, Sun, Hao-Peng, Wang, Xiao-Long, Li, Nian-Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2016
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5162400/
https://www.ncbi.nlm.nih.gov/pubmed/27994971
http://dx.doi.org/10.7717/peerj.2757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5162400/
https://www.ncbi.nlm.nih.gov/pubmed/27994971
http://dx.doi.org/10.7717/peerj.2757

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