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Midkine Is a Novel Regulator of Amphetamine-Induced Striatal Gliosis and Cognitive Impairment: Evidence for a Stimulus-Dependent Regulation of Neuroinflammation by Midkine

Midkine (MK) is a cytokine that modulates amphetamine-induced striatal astrogliosis, suggesting a possible role of MK in neuroinflammation induced by amphetamine. To test this hypothesis, we studied astrogliosis and microglial response induced by amphetamine (10 mg/kg i.p. four times, every 2 h) in...

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Detalles Bibliográficos
Autores principales: Vicente-Rodríguez, Marta, Fernández-Calle, Rosalía, Gramage, Esther, Pérez-García, Carmen, Ramos, María P., Herradón, Gonzalo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164901/
https://www.ncbi.nlm.nih.gov/pubmed/28044069
http://dx.doi.org/10.1155/2016/9894504