Genome-wide genetic screening with chemically-mutagenized haploid embryonic stem cells

In model organisms, classical genetic screening via random mutagenesis provides key insights into the molecular bases of genetic interactions, helping defining synthetic-lethality, synthetic-viability and drug-resistance mechanisms. The limited genetic tractability of diploid mammalian cells, howeve...

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Detalles Bibliográficos
Autores principales: Forment, Josep V., Herzog, Mareike, Coates, Julia, Konopka, Tomasz, Gapp, Bianca V., Nijman, Sebastian M., Adams, David J., Keane, Thomas M., Jackson, Stephen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164930/
https://www.ncbi.nlm.nih.gov/pubmed/27820796
http://dx.doi.org/10.1038/nchembio.2226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164930/
https://www.ncbi.nlm.nih.gov/pubmed/27820796
http://dx.doi.org/10.1038/nchembio.2226

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