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Genome-wide genetic screening with chemically-mutagenized haploid embryonic stem cells

In model organisms, classical genetic screening via random mutagenesis provides key insights into the molecular bases of genetic interactions, helping defining synthetic-lethality, synthetic-viability and drug-resistance mechanisms. The limited genetic tractability of diploid mammalian cells, howeve...

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Detalles Bibliográficos
Autores principales:	Forment, Josep V., Herzog, Mareike, Coates, Julia, Konopka, Tomasz, Gapp, Bianca V., Nijman, Sebastian M., Adams, David J., Keane, Thomas M., Jackson, Stephen P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164930/ https://www.ncbi.nlm.nih.gov/pubmed/27820796 http://dx.doi.org/10.1038/nchembio.2226

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