Cargando…

Prediction of Differentiation Tendency Toward Hepatocytes from Gene Expression in Undifferentiated Human Pluripotent Stem Cells

Functional hepatocytes derived from human pluripotent stem cells (hPSCs) have potential as tools for predicting drug-induced hepatotoxicity in the early phases of drug development. However, the propensity of hPSC lines to differentiate into specific lineages is reported to differ. The ability to pre...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yanagihara, Kana, Liu, Yujung, Kanie, Kei, Takayama, Kazuo, Kokunugi, Minako, Hirata, Mitsuhi, Fukuda, Takayuki, Suga, Mika, Nikawa, Hiroki, Mizuguchi, Hiroyuki, Kato, Ryuji, Furue, Miho K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc. 2016
Materias:	Original Research Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5165660/ https://www.ncbi.nlm.nih.gov/pubmed/27733097 http://dx.doi.org/10.1089/scd.2016.0099

Ejemplares similares

Protein Kinase C Regulates Human Pluripotent Stem Cell Self-Renewal
por: Kinehara, Masaki, et al.
Publicado: (2013)

Parametric analysis of colony morphology of non-labelled live human pluripotent stem cells for cell quality control
por: Kato, Ryuji, et al.
Publicado: (2016)

Imaging-cytometry revealed spatial heterogeneities of marker expression in undifferentiated human pluripotent stem cells
por: Suga, Mika, et al.
Publicado: (2016)

Comparison of commercially available media for hepatic differentiation and hepatocyte maintenance
por: Toba, Yukiko, et al.
Publicado: (2020)

Generation of a bile salt export pump deficiency model using patient-specific induced pluripotent stem cell-derived hepatocyte-like cells
por: Imagawa, Kazuo, et al.
Publicado: (2017)

Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection
por: Sakurai, Fuminori, et al.
Publicado: (2017)

Enzyme-free Passage of Human Pluripotent Stem Cells by Controlling Divalent Cations
por: Ohnuma, Kiyoshi, et al.
Publicado: (2014)

Generation of safe and therapeutically effective human induced pluripotent stem cell‐derived hepatocyte‐like cells for regenerative medicine
por: Takayama, Kazuo, et al.
Publicado: (2017)

Vinblastine treatment decreases the undifferentiated cell contamination of human iPSC-derived intestinal epithelial-like cells
por: Ichikawa, Moe, et al.
Publicado: (2021)

Establishment of SLC15A1/PEPT1-Knockout Human-Induced Pluripotent Stem Cell Line for Intestinal Drug Absorption Studies
por: Kawai, Kanae, et al.
Publicado: (2019)

Generation of Brain Microvascular Endothelial-Like Cells from Human Induced Pluripotent Stem Cells by Co-Culture with C6 Glioma Cells
por: Minami, Haruka, et al.
Publicado: (2015)

Biological Effects of Culture Substrates on Human Pluripotent Stem Cells
por: Hayashi, Yohei, et al.
Publicado: (2016)

In Vitro Model for a Drug Assessment of Cytochrome P450 Family 3 Subfamily A Member 4 Substrates Using Human Induced Pluripotent Stem Cells and Genome Editing Technology
por: Deguchi, Sayaka, et al.
Publicado: (2021)

Efficient and Directive Generation of Two Distinct Endoderm Lineages from Human ESCs and iPSCs by Differentiation Stage-Specific SOX17 Transduction
por: Takayama, Kazuo, et al.
Publicado: (2011)

Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction
por: Nakamori, Daiki, et al.
Publicado: (2017)

Conditionally replicating adenovirus prevents pluripotent stem cell–derived teratoma by specifically eliminating undifferentiated cells
por: Mitsui, Kaoru, et al.
Publicado: (2015)

Decellularized Organ-Derived Scaffold Is a Promising Carrier for Human Induced Pluripotent Stem Cells-Derived Hepatocytes
por: Kojima, Hideaki, et al.
Publicado: (2022)

Development of selective cytotoxic viral vectors for concentration of undifferentiated cells in cardiomyocytes derived from human induced pluripotent stem cells
por: Kono, Ken, et al.
Publicado: (2019)

The pluripotency factor LIN28 marks undifferentiated spermatogonia in mouse
por: Zheng, Ke, et al.
Publicado: (2009)

Possibility of Undifferentiated Human Thigh Adipose Stem Cells Differentiating into Functional Hepatocytes
por: Lee, Jong Hoon, et al.
Publicado: (2012)

Reduction of N-Glycolylneuraminic Acid in Human Induced Pluripotent Stem Cells Generated or Cultured under Feeder- and Serum-Free Defined Conditions
por: Hayashi, Yohei, et al.
Publicado: (2010)

HHEX Promotes Hepatic-Lineage Specification through the Negative Regulation of Eomesodermin
por: Watanabe, Hitoshi, et al.
Publicado: (2014)

Pluripotent stem cell-based therapies and their path to the clinic
por: Takayama, Kazuo, et al.
Publicado: (2023)

Generation of enterocyte-like cells from human induced pluripotent stem cells for drug absorption and metabolism studies in human small intestine
por: Ozawa, Tatsuya, et al.
Publicado: (2015)

Hepatocytic parental progenitor cells of rat small hepatocytes maintain self-renewal capability after long-term culture
por: Ishii, Masayuki, et al.
Publicado: (2017)

Effect of mechanical vibration stress in cell culture on human induced pluripotent stem cells
por: Kanie, Kei, et al.
Publicado: (2019)

Expression of Chrna9 is regulated by Tbx3 in undifferentiated pluripotent stem cells
por: Yazawa, Takashi, et al.
Publicado: (2023)

Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies
por: Negoro, Ryosuke, et al.
Publicado: (2018)

Adenovirus vector-mediated macrophage erythroblast attacher (MAEA) overexpression in primary mouse hepatocytes attenuates hepatic gluconeogenesis
por: Shimizu, Kahori, et al.
Publicado: (2017)

Tolloid‐Like 1 Negatively Regulates Hepatic Differentiation of Human Induced Pluripotent Stem Cells Through Transforming Growth Factor Beta Signaling
por: Kiso, Ayumi, et al.
Publicado: (2020)

Intramyocardial Transplantation of Undifferentiated Rat Induced Pluripotent Stem Cells Causes Tumorigenesis in the Heart
por: Zhang, Yuzhen, et al.
Publicado: (2011)

MicroRNA-302 switch to identify and eliminate undifferentiated human pluripotent stem cells
por: Parr, Callum J. C., et al.
Publicado: (2016)

Plasma-activated medium selectively eliminates undifferentiated human induced pluripotent stem cells
por: Matsumoto, Ryo, et al.
Publicado: (2016)

A dramatic course after the resection of an SMARCA4‐deficient undifferentiated tumour
por: Iguchi, Takafumi, et al.
Publicado: (2022)

Advantages and difficulties in culturing human pluripotent stem cells in growth factor-defined serum-free medium
por: Kusuda Furue, Miho, et al.
Publicado: (2010)

Visualization of morphological categories of colonies for monitoring of effect on induced pluripotent stem cell culture status
por: Nagasaka, Risako, et al.
Publicado: (2017)

Sialyl-lactotetra, a Novel Cell Surface Marker of Undifferentiated Human Pluripotent Stem Cells
por: Barone, Angela, et al.
Publicado: (2014)

Method for selective ablation of undifferentiated human pluripotent stem cell populations for cell-based therapies
por: Chour, Tony, et al.
Publicado: (2021)

Undifferentiated Induced Pluripotent Stem Cells as a Genetic Model for Nonalcoholic Fatty Liver Disease
por: Muñoz, Antonio, et al.
Publicado: (2022)

Collagen vitrigel promotes hepatocytic differentiation of induced pluripotent stem cells into functional hepatocyte-like cells
por: Nakai, Shun, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_5s99m9i8253nrusljok4ba2oss