Natural killer cell granules converge to avoid collateral damage

To clear infection, cytotoxic lymphocytes must destroy target cells while avoiding nonspecific killing of surrounding healthy cells. In this issue, Hsu et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201604136) use live-cell imaging to show that lytic granule convergence protects bystander c...

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Detalles Bibliográficos
Autores principales: Ritter, Alex T., Mellman, Ira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5166509/
https://www.ncbi.nlm.nih.gov/pubmed/27932575
http://dx.doi.org/10.1083/jcb.201612003
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author Ritter, Alex T.
Mellman, Ira
author_facet Ritter, Alex T.
Mellman, Ira
author_sort Ritter, Alex T.
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description To clear infection, cytotoxic lymphocytes must destroy target cells while avoiding nonspecific killing of surrounding healthy cells. In this issue, Hsu et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201604136) use live-cell imaging to show that lytic granule convergence protects bystander cells from unintended death by promoting polarized secretion of soluble cytolytic proteins toward the intended target.
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spelling pubmed-51665092017-06-19 Natural killer cell granules converge to avoid collateral damage Ritter, Alex T. Mellman, Ira J Cell Biol Commentary To clear infection, cytotoxic lymphocytes must destroy target cells while avoiding nonspecific killing of surrounding healthy cells. In this issue, Hsu et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201604136) use live-cell imaging to show that lytic granule convergence protects bystander cells from unintended death by promoting polarized secretion of soluble cytolytic proteins toward the intended target. The Rockefeller University Press 2016-12-19 /pmc/articles/PMC5166509/ /pubmed/27932575 http://dx.doi.org/10.1083/jcb.201612003 Text en © 2016 Ritter and Mellman This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Ritter, Alex T.
Mellman, Ira
Natural killer cell granules converge to avoid collateral damage
title Natural killer cell granules converge to avoid collateral damage
title_full Natural killer cell granules converge to avoid collateral damage
title_fullStr Natural killer cell granules converge to avoid collateral damage
title_full_unstemmed Natural killer cell granules converge to avoid collateral damage
title_short Natural killer cell granules converge to avoid collateral damage
title_sort natural killer cell granules converge to avoid collateral damage
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5166509/
https://www.ncbi.nlm.nih.gov/pubmed/27932575
http://dx.doi.org/10.1083/jcb.201612003
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