The Role of BCA2 in the Endocytic Trafficking of EGFR and Significance as a Prognostic Biomarker in Cancer

Breast Cancer Associated gene 2 (BCA2) is an E3 ubiquitin ligase that is over-expressed in >50% of primary breast cancers, and has been shown to increase in vitro cell proliferation and invasion. The protein has been linked to alterations in EGFR degradation; however there is some dispute as to i...

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Detalles Bibliográficos
Autores principales: Wymant, Jennifer M., Hiscox, Stephen, Westwell, Andrew D., Urbé, Sylvie, Clague, Michael J., Jones, Arwyn T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5166551/
https://www.ncbi.nlm.nih.gov/pubmed/27994678
http://dx.doi.org/10.7150/jca.15055

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5166551/
https://www.ncbi.nlm.nih.gov/pubmed/27994678
http://dx.doi.org/10.7150/jca.15055

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