Transbuccal delivery of betahistine dihydrochloride from mucoadhesive tablets with a unidirectional drug flow: in vitro, ex vivo and in vivo evaluation

OBJECTIVE: Betahistine dihydrochloride (BH.2HCl), an anti-vertigo histamine analog used in the treatment of Ménière’s disease, undergoes extensive first-pass metabolism and suffers from short biological half-life. The aim of the present work was to develop and estimate controlled release mucoadhesiv...

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Detalles Bibliográficos
Autores principales: El-Nabarawi, Mohamed A, Ali, Adel A, Aboud, Heba M, Hassan, Amira H, Godah, Amany H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167456/
https://www.ncbi.nlm.nih.gov/pubmed/28008227
http://dx.doi.org/10.2147/DDDT.S120613

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167456/
https://www.ncbi.nlm.nih.gov/pubmed/28008227
http://dx.doi.org/10.2147/DDDT.S120613

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